Mechanical strain promotes osteoblast ECM formation and improves its osteoinductive potential
نویسندگان
چکیده
منابع مشابه
Mechanical strain promotes osteoblast ECM formation and improves its osteoinductive potential
BACKGROUND The extracellular matrix (ECM) provides a supportive microenvironment for cells, which is suitable as a tissue engineering scaffold. Mechanical stimulus plays a significant role in the fate of osteoblast, suggesting that it regulates ECM formation. Therefore, we investigated the influence of mechanical stimulus on ECM formation and bioactivity. METHODS Mouse osteoblastic MC3T3-E1 c...
متن کاملA comparative study of mechanical strain, icariin and combination stimulations on improving osteoinductive potential via NF-kappaB activation in osteoblast-like cells
BACKGROUND The combination of drugs and exercise was the effective treatment in bone injure and rebuilding in clinic. As mechanical strain has potential in inducing the differentiation of osteoblasts in our previous study, the further research to investigate the combination of mechanical strain and icariin stimulation on inducing osteoblast proliferation, differentiation and the possible mechan...
متن کاملMechanical Strain Regulates Osteoblast Proliferation through Integrin-Mediated ERK Activation
Mechanical strain plays a critical role in the proliferation, differentiation and maturation of bone cells. As mechanical receptor cells, osteoblasts perceive and respond to stress force, such as those associated with compression, strain and shear stress. However, the underlying molecular mechanisms of this process remain unclear. Using a four-point bending device, mouse MC3T3-E1 cells was expo...
متن کاملTransient ECM protease activity promotes synaptic plasticity
Activity-dependent proteolysis at a synapse has been recognized as a pivotal factor in controlling dynamic changes in dendritic spine shape and function; however, excessive proteolytic activity is detrimental to the cells. The exact mechanism of control of these seemingly contradictory outcomes of protease activity remains unknown. Here, we reveal that dendritic spine maturation is strictly con...
متن کاملOsteoblast Genotypic Response and Matrix Formation: Effect of Scaffold Morphology and Mechanical Stimuli in vitro
Introduction Tissue scaffolds can be fabricated by various methods to produce highly porous and resorbable constructs with tunable morphologies that offer a suitable network for 3D cellular geometries as well as mechanical support for the ensuing tissue growth. In the case of bone tissue, the natural cellular network is ingeniously designed to exhibit mechanical resilience and strength; therefo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioMedical Engineering OnLine
سال: 2012
ISSN: 1475-925X
DOI: 10.1186/1475-925x-11-80